Ethyl Acetate → 1-(Benzothiazol-6-ylamino)-butan-2-one

HRID 2383907

Reaktionsgleichung

Reaktionsgleichung von HRID 2383907
C([O-])(=O)C.[Na+].Br[CH2:7][C:8](=[O:11])[CH2:9][CH3:10].[S:12]1[C:16]2[CH:17]=[C:18]([NH2:21])[CH:19]=[CH:20][C:15]=2[N:14]=[CH:13]1.C(OCC)(=O)C>CO.CCCCCC>[S:12]1[C:16]2[CH:17]=[C:18]([NH:21][CH2:7][C:8](=[O:11])[CH2:9][CH3:10])[CH:19]=[CH:20][C:15]=2[N:14]=[CH:13]1

Komponenten

7

Edukt 4

HCID 8857Ethyl AcetateHCID 131561-Bromo-2-butanoneHCID 682886-AminobenzothiazoleHCID 517045Sodium Acetate

Produkt 1

HCID 596361951-(Benzothiazol-6-ylamino)-butan-2-oneAusbeute 34,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8058HexaneLösungsmittel

Versuchsvorschrift

Sodium acetate (300 mg, 3.66 mmol) and 1-bromo-butan-2-one (0.373 mL, 3.66 mmol) were added to a stirred solution of benzothiazol-6-ylamine (500 mg, 3.328 mmol) in methanol (10 mL) under nitrogen atmosphere. The resulting reaction mass was stirred at room temperature for 24 hours. The reaction was monitored by TLC (20% ethyl acetate in hexane). The reaction mixture was filtered and the solid collected was dried under reduced pressure to afford 250 mg of the product (32% yield).

Aufarbeitung

  1. customThe resulting reaction mass
  2. filtrationThe reaction mixture was filtered
  3. customthe solid collected
  4. customwas dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7adb840d11424fd2a79c0e22e8c79c41
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08263635B2

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