Acetic Acid → (3-Amino-6-bromo-5-methylpyrazin-2-yl)(phenyl)methanone

Reaktionsgleichung

C(=O)([O-])[O-].[K+].[K+].C(O)(=O)C.[NH2:11][C:12]1[C:13]([C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:20])=[N:14][CH:15]=[C:16]([CH3:18])[N:17]=1.[Br:27]Br>>[NH2:11][C:12]1[C:13]([C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:20])=[N:14][C:15]([Br:27])=[C:16]([CH3:18])[N:17]=1

Komponenten

Edukt 4

HCID 176Acetic Acid

HCID 11430Potassium Carbonate

HCID 24408Bromine

HCID 68631897(3-Amino-5-methyl-pyrazin-2-yl)-phenyl-methanone

Produkt 1

HCID 87523235(3-Amino-6-bromo-5-methylpyrazin-2-yl)(phenyl)methanone

Versuchsvorschrift

Potassium carbonate (0.23 g, 1.64 mmol) is dissolved in glacial acetic acid (5 ml, 1.64 mmol) and (3-amino-5-methyl-pyrazin-2-yl)-phenyl-methanone (0.17 g, 0.82 mmol) and bromine (0.055 ml, 1.07 mmol) are added. The resulting yellow solution is stirred at room temperature for 1.5 hours. The solvent is removed in vacuo, and the residue is suspended in DCM, filtered and washed with DCM. The filtrated is concentrated and dried in vacuo to yield the title compound as a yellow solid. [M+H]+ 292.