Lithium Hydroxide → 2-(4-((2-Amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-hydroxyphenyl)acetic acid

HRID 2387880

Reaktionsgleichung

Reaktionsgleichung von HRID 2387880
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:21]([O:23]C)=[O:22])=[CH:16][C:15]=2[OH:25])=[C:4]([CH3:26])[N:3]=1.[Li+].[OH-]>C1COCC1.O>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:21]([OH:23])=[O:22])=[CH:16][C:15]=2[OH:25])=[C:4]([CH3:26])[N:3]=1

Komponenten

5

Edukt 2

HCID 3939Lithium HydroxideHCID 42613680Methyl 2-(4-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-hydroxyphenyl)acetate

Produkt 1

HCID 684141362-(4-((2-Amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-hydroxyphenyl)acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To the product of example 77 (100 mg) in THF (5 mL), LiOH (35.1 mg) in water (5 mL) was added and stirred for 16 h at rt. The solvent was evaporated, the residue redissolved in water and AcOH was added. The precipitate was filtered and dried to give the subtitle compound as a white solid, 50 mg.

Aufarbeitung

  1. customThe solvent was evaporated
  2. dissolutionthe residue redissolved in water
  3. additionAcOH was added
  4. filtrationThe precipitate was filtered
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-432c203db9ca48eaab0e960d5acb7493
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08268990B2

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