Hydrochloric Acid → 2-Furanacrylic acid

HRID 2389863

Reaktionsgleichung

Reaktionsgleichung von HRID 2389863
[CH:1]1[CH:5]=[C:4]([CH:6]=O)[O:3][CH:2]=1.C(O)(=O)[CH2:9][C:10]([OH:12])=[O:11].N1CCCCC1.Cl>N1C=CC=CC=1.O>[O:3]1[CH:2]=[CH:1][CH:5]=[C:4]1/[CH:6]=[CH:9]/[C:10]([OH:12])=[O:11]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 7362FurfuralHCID 8082Piperidine

Produkt 1

HCID 6434022-Furanacrylic acidAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a mixture of 2-furfural (500 g, 5.20 mol) and malonic acid (595 g, 5.72 mol) in pyridine (500 mL) was added piperidine (50 mL, 0.505 mol) at room temperature, and the mixture was stirred at 100° C. for 3 hr. The reaction solution was poured into water (1 L) and acidified with 6M hydrochloric acid. The resulting precipitate was collected by filtration to give the title compound (660 g, yield 92%).

Aufarbeitung

  1. filtrationThe resulting precipitate was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-f4f5782bb6ab4fe5b912f3315f5b6e9d
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08273761B2

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