Hydrochloric Acid → 1-(3,5-Dibromophenyl)ethanone

HRID 2391099

Reaktionsgleichung

Reaktionsgleichung von HRID 2391099
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:11])[CH:10]=1)[C:5]([OH:7])=O.C[Li].[CH3:14]COC(C)=O.Cl>CCOCC>[Br:11][C:9]1[CH:8]=[C:4]([C:5](=[O:7])[CH3:14])[CH:3]=[C:2]([Br:1])[CH:10]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 12063Benzoic acid, 3,5-dibromo-HCID 178418348HCID 178418348, Verbindung

Produkt 1

HCID 6218251-(3,5-Dibromophenyl)ethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a solution of 3,5-dibromobenzoic acid (2.5 g, 8.9 mmol) in Et2O (30 mL) at 0° C. was added methyllithium (1.6M in Et2O; 12.3 mL, 19.6 mmol) dropwise. The reaction was stirred at 0° C. for 2 hours, and then worked-up with EtOAc and 10% aqueous HCl. The crude material was purified by silica gel chromatography to give the title compound.

Aufarbeitung

  1. customThe crude material was purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-478e695e1dad4f818306169e89307e2c
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08273780B2

Verknüpfte Notizen

Wird geladen…