OO.C([C:6]1[CH:18]=[CH:17][C:9]([O:10][C@H:11]([CH3:16])[C:12]([O:14][CH3:15])=[O:13])=[CH:8][CH:7]=1)(=O)C.S([O-])([O-])=O.[Na+].[Na+]>O.C(O)=O>[C:12]([O:14][C:6]1[CH:7]=[CH:8][C:9]([O:10][C@H:11]([CH3:16])[C:12]([O:14][CH3:15])=[O:13])=[CH:17][CH:18]=1)(=[O:13])[CH3:11]
54.4 g (0.48 mol) of a 30% strength solution of hydrogen peroxide in water was added dropwise to the solution of 88.93 g (0.4 mol) of methyl (R)-2-(4-acetylphenoxy)propionate in 356 g of formic acid at 35° C. over the course of 1 h. After stirring at 35° C. for 5 hours, the excess hydrogen peroxide was decomposed with 5 g of sodium sulfite. The mixture was finally concentrated under reduced pressure and subjected to a short-path distillation at 150°-160° C. under 0.5 mbar. Yield: 96% (94-95% enantiomeric excess).
Wird geladen…
