Tetrahydrofuran → 2-Quinolinecarboxylic acid, 5-bromo-8-methoxy-

HRID 2393093Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2393093
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([C:14]([O:16]C)=[O:15])=[N:7]2.O1CCCC1.O.[OH-].[Li+]>O>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([C:14]([OH:16])=[O:15])=[N:7]2

Komponenten

5

Edukt 3

HCID 8028TetrahydrofuranHCID 168937Lithium hydroxide, monohydrateHCID 9900802HCID 9900802, Verbindung

Produkt 1

HCID 99436352-Quinolinecarboxylic acid, 5-bromo-8-methoxy-Ausbeute 0,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Methyl 5-bromo-8-methoxyquinoline-2-carboxylate (154 g), tetrahydrofuran (40 ml), water (40 ml) and lithium hydroxide monohydrate (0.436 g) were combined and stirred at room temperature for 1.5 h. The tetrahydrofuran was removed in vacuo and the resulting aqueous mixture was acidified with hydrochloric acid. The resulting white precipitate was collected by filtration and dried in vacuo to give the title compound (1.33 g) as a white solid.

Aufarbeitung

  1. customThe tetrahydrofuran was removed in vacuo
  2. filtrationThe resulting white precipitate was collected by filtration
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1c10f43d65074e3585a16ba9b4f4a23f
Quelldatensatz
uspto-grants-1998_09
Patentnummer
US05804588

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