Chloroform → 2-(1-Hydroxyiminoethyl)-4-[4-(2-hydroxyethyl)piperazin-1-ylmethyl]phenol

HRID 23936Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 23936
Cl.[NH2:2][OH:3].C(=O)(O)[O-].[Na+].[C:9]([C:12]1[CH:17]=[C:16]([CH2:18][N:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][OH:27])[CH2:21][CH2:20]2)[CH:15]=[CH:14][C:13]=1[OH:28])(=O)[CH3:10].C(Cl)(Cl)Cl>O.CO>[OH:3][N:2]=[C:9]([C:12]1[CH:17]=[C:16]([CH2:18][N:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][OH:27])[CH2:21][CH2:20]2)[CH:15]=[CH:14][C:13]=1[OH:28])[CH3:10]

Komponenten

7

Edukt 4

HCID 6212ChloroformHCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 98604522-Acetyl-4-[4-(2-hydroxyethyl)piperazin-1-yl-methyl]phenol

Produkt 1

HCID 1359919502-(1-Hydroxyiminoethyl)-4-[4-(2-hydroxyethyl)piperazin-1-ylmethyl]phenolAusbeute 81 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

Hydroxylamine hydrochloride (63 mg, 0.9 mmol) and sodium bicarbonate (76 mg, 0.9 mmol) were dissolved in distilled water (1 ml). 2-Acetyl-4-[4-(2-hydroxyethyl)-piperazin-1-yl-methyl]phenol (85 mg, 0.3 mmol) in absolute methanol (2 ml) was added and the reaction mixture was stirred at 65° C. for 24 h. CHCl3 (20 ml) was then added, the organic phase washed with water followed by brine, dried over Na2SO4, filtered and evaporated to obtain the title product (52 mg, 81%).

Aufarbeitung

  1. washthe organic phase washed with water
  2. dry with materialdried over Na2SO4
  3. filtrationfiltered
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-16df7836f55644e0b2139ea2dbbfac49
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06855711B1

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