Oxalyl chloride → 2-Cyano-4-(trifluoromethyl)-5-pyrimidinecarbonyl chloride
Reaktionsgleichung
[C:1]([C:3]1[N:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[C:6]([C:13]([OH:15])=O)=[CH:5][N:4]=1)#[N:2].C(Cl)(=O)C([Cl:19])=O>CN(C=O)C.ClCl>[C:1]([C:3]1[N:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[C:6]([C:13]([Cl:19])=[O:15])=[CH:5][N:4]=1)#[N:2]Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of 2-cyano-4-trifluoromethylpyrimidine-5-carboxylic acid (2.0 g, 9.2 mmol), oxalyl chloride (1.4 g, 11 mmol) and DMF (4 drops) in CH2 Cl2 (46 mL) was stirred at room temperature under N2 for 0.75 h. The reaction was concentrated and distilled (b.p. 100° C., 1.5 mm/Hg) to give the title compound (1.8 g, 82% yield); 1HNMR (CDCl3) δ 9.49 (s, 1H).
Aufarbeitung
- concentrationThe reaction was concentrated
- distillationdistilled (b.p. 100° C., 1.5 mm/Hg)
Quellen und Nachweise
- ORD-Eintrag
- ord-dd830d0144254084ac1e1e3106c68e28
- Quelldatensatz
- uspto-grants-1998_09
- Patentnummer
- US05811428
Notizen zur Reaktion
Wird geladen…