Water → BIS-(beta-M-CHLOROBENZAMIDOETHYL)SULFIDE

HRID 2397175

Reaktionsgleichung

Reaktionsgleichung von HRID 2397175
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][CH2:6][NH2:7].[OH-:8].[Na+].O.[Cl:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][CH:20]=1)[C:15](Cl)=[O:16]>CCOCC>[Cl:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][CH:20]=1)[C:15]([NH:1][CH2:2][CH2:3][S:4][CH2:5][CH2:6][NH:7][C:15](=[O:8])[C:14]1[CH:18]=[CH:19][CH:20]=[C:12]([Cl:11])[CH:13]=1)=[O:16]

Komponenten

6

Edukt 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 69252Benzoyl chloride, 3-chloro-HCID 700962,2'-Thiobis(ethanamine)

Produkt 1

HCID 22749424BIS-(beta-M-CHLOROBENZAMIDOETHYL)SULFIDE

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

To a solution of bis-(β-aminoethyl)sulfide (2.5 g., 0.021 M) and sodium hydroxide (1.6 g., 0.04 M) in 20 ml. of water and 40 ml. of ether was added a solution of m-chlorobenzoyl chloride (7.0 g., 0.04 M) in 15 ml. of ether at 10°-20° C. A precipitate appeared. The mixture was stirred 45 minutes at room temperature and the solid filtered, washed with water and dried. The product was a white solid. m.p. 150°-152° C. Its structure was confirmed by IR spectroscopy. Yield: 7.0 g. (88%).

Aufarbeitung

  1. customat 10°-20° C
  2. filtrationthe solid filtered
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-7f583b4b5f8842d4914740115c99b2ee
Quelldatensatz
uspto-grants-1977_05
Patentnummer
US04021228

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