2,2-Dimethyl-1,3-dioxane-4,6-dione → 6-(Trifluoromethoxy)-2-oxo-2H-chromene-3-carboxylic acid

HRID 240034

Reaktionsgleichung

Reaktionsgleichung von HRID 240034
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:11]=[C:8]([CH:9]=O)[C:7]([OH:12])=[CH:6][CH:5]=1.CC1(C)O[C:21](=[O:22])[CH2:20][C:18](=[O:19])[O:17]1>O>[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:11]=[C:8]2[C:7](=[CH:6][CH:5]=1)[O:12][C:21](=[O:22])[C:20]([C:18]([OH:19])=[O:17])=[CH:9]2

Komponenten

4

Edukt 2

HCID 162492,2-Dimethyl-1,3-dioxane-4,6-dioneHCID 12680582-Hydroxy-5-(trifluoromethoxy)benzaldehyde

Produkt 1

HCID 100618686-(Trifluoromethoxy)-2-oxo-2H-chromene-3-carboxylic acidAusbeute 50 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

5-trifluoromethoxy-salicylaldehyde (286.0 mg, 1.39 mmol) and Meldrum's acid (200 mg, 1.39 mmol) were combined in H2O (2 mL). The solution was stirred at 75° C. for 2 h. After cooling to room temperature, the precipitate was filtered and dried at suction to give 189.1 mg of 6-trifluoromethoxy-3-carboxy-coumarin in a 50% yield.

Aufarbeitung

  1. temperatureAfter cooling to room temperature
  2. filtrationthe precipitate was filtered
  3. customdried at suction

Quellen und Nachweise

ORD-Eintrag
ord-75c7661c2c424a7abc926de33611af6d
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08642788B2

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