Phosphorus oxychloride → 4-Chloro-6-nitroquinazoline

HRID 240567

Reaktionsgleichung

Reaktionsgleichung von HRID 240567
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][N:8]=[C:7]2O)([O-:3])=[O:2].C(N(C(C)C)C(C)C)C.P(Cl)(Cl)([Cl:26])=O>ClC(Cl)C>[Cl:26][C:7]1[C:6]2[C:11](=[CH:12][CH:13]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[N:10]=[CH:9][N:8]=1

Komponenten

5

Edukt 3

HCID 24813Phosphorus oxychlorideHCID 81531DiisopropylethylamineHCID 178526470HCID 178526470, Verbindung

Produkt 1

HCID 113562574-Chloro-6-nitroquinazoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 63651,1-DichloroethaneLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution of 6-nitroquinazolin-4-ol (4.40 g, 23.01 mmol) and N-ethyl-N-isopropylpropan-2-amine (11.89 g, 92.04 mmol) in dichloroethane (50 mL) was added phosphoryl trichloride (7.06 g, 46.02 mmol). After heating to 80° C. for 16 hours, the mixture was concentrated under reduced pressure. The residue was concentrated again with toluene (2×100 mL) to provide the product.

Aufarbeitung

  1. concentrationthe mixture was concentrated under reduced pressure
  2. concentrationThe residue was concentrated again with toluene (2×100 mL)
  3. customto provide the product

Quellen und Nachweise

ORD-Eintrag
ord-d1eed894f6634d29a3b589e41d38d8f6
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08648087B2

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