Acetic Anhydride → HCID 58413204, Verbindung
Reaktionsgleichung
[C:1]([O:5][C:6]([N:8]1[C@H:12]([CH2:13][OH:14])[CH2:11][C@H:10]([O:15][C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=2[NH:23][C:24]2[C:25]3[C:32]([CH3:33])=[C:31]([C:34]([NH2:36])=[O:35])[S:30][C:26]=3[N:27]=[CH:28][N:29]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:37](OC(=O)C)(=[O:39])[CH3:38]>CN(C1C=CN=CC=1)C>[C:1]([O:5][C:6]([N:8]1[CH2:9][C@@H:10]([O:15][C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=2[NH:23][C:24]2[C:25]3[C:32]([CH3:33])=[C:31]([C:34](=[O:35])[NH2:36])[S:30][C:26]=3[N:27]=[CH:28][N:29]=2)[CH2:11][C@H:12]1[CH2:13][O:14][C:37](=[O:39])[CH3:38])=[O:7])([CH3:4])([CH3:2])[CH3:3]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Prepared analogously to example 96.4 from 4-[2-((3S,5S)-1-tert-butoxycarbonyl-5-hydroxymethyl-pyrrolidin-3-yloxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid amide and acetic anhydride. The acetic anhydride was added at 0° C. and a catalytic amount of DMAP was used.