Lithium hydroxide, monohydrate → (3R)-5-(5-chloro-2-hexyl-1-methylindol-3-yl)-3-methyl-5-oxopentanoic acid

HRID 2406653Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2406653
C[O:2][C:3](=[O:27])[CH2:4][C@H:5]([CH3:26])[CH2:6][C:7]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([Cl:18])[CH:16]=2)[N:11]([CH3:19])[C:10]=1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[O:8].O.[OH-].[Li+]>C(O)(C)C.O>[Cl:18][C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[N:11]([CH3:19])[C:10]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[C:9]2[C:7](=[O:8])[CH2:6][C@@H:5]([CH3:26])[CH2:4][C:3]([OH:27])=[O:2]

Komponenten

5

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 66644148Methyl 5-(5-chloro-2-hexyl-1-methyl-1H-indol-3-yl)-3-(R)-methyl-5-oxopentanoate

Produkt 1

HCID 49802026(3R)-5-(5-chloro-2-hexyl-1-methylindol-3-yl)-3-methyl-5-oxopentanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

To the solution of Methyl-5-(5-chloro-2-hexyl-1-methyl-1H-indol-3-yl)-3-(R)-methyl-5-oxopentanoate in iso-propanol and water was added lithium hydroxide monohydrate and was stirred at RT for three hours. The product was purified by column chromatography.

Aufarbeitung

  1. customThe product was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-e9ab8f561224433e8a012cb380e93e48
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08809382B2

Notizen zur Reaktion

Wird geladen…