Lithium hydroxide, monohydrate → (3R)-5-(5-chloro-2-hexyl-1-methylindol-3-yl)-3-methyl-5-oxopentanoic acid

HRID 2406659Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2406659
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[C:5]2[C:18](=[O:27])[CH2:19][C@@H:20]([CH3:26])[CH2:21][C:22]([O:24]C)=[O:23].O.[OH-].[Li+]>C(O)(C)C.O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[C:5]2[C:18](=[O:27])[CH2:19][C@@H:20]([CH3:26])[CH2:21][C:22]([OH:24])=[O:23]

Komponenten

5

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 66644148Methyl 5-(5-chloro-2-hexyl-1-methyl-1H-indol-3-yl)-3-(R)-methyl-5-oxopentanoate

Produkt 1

HCID 49802026(3R)-5-(5-chloro-2-hexyl-1-methylindol-3-yl)-3-methyl-5-oxopentanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

To the solution of Methyl 5-(5-chloro-2-hexyl-1-methyl-1H-indol-3-yl)-3-(R)-methyl-5-oxopentanoate in iso-propanol and water was added lithium hydroxide monohydrate and was stirred at RT for three hours. The product was purified by column chromatography.

Aufarbeitung

  1. customThe product was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-d5da485483a64fdb81de973b4ce0f4a5
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08809382B2

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