Morpholine → 5-nitro-2-morpholino-3-(2H-1,2,3-triazol-2-yl)pyridine

Reaktionsgleichung

[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.O1CCOCC1.Cl[C:14]1[C:19]([N:20]2[N:24]=[CH:23][CH:22]=[N:21]2)=[CH:18][C:17]([N+:25]([O-:27])=[O:26])=[CH:16][N:15]=1>O>[N+:25]([C:17]1[CH:18]=[C:19]([N:20]2[N:24]=[CH:23][CH:22]=[N:21]2)[C:14]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[N:15][CH:16]=1)([O-:27])=[O:26]

Komponenten

Versuchsvorschrift

Morpholine (0.5 ml) was added to a 1,4-dioxane solution (1 ml) containing 2-chloro-5-nitro-3-(2H-1,2,3-triazol-2-yl)pyridine (30 mg), followed by stirring at room temperature for 30 minutes. Water was added to the reaction solution, followed by extraction with ethyl acetate. The resultant was washed with saturated saline and dried over anhydrous sodium sulfate, the solvent was distilled away under reduced pressure, and a yellow solid of 5-nitro-2-morpholino-3-(2H-1,2,3-triazol-2-yl)pyridine (33 mg) was thus obtained.