Oxalyl chloride → 2-Furancarbonylisocyanate

HRID 2412478

Reaktionsgleichung

Reaktionsgleichung von HRID 2412478
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([NH2:8])=[O:7].C(Cl)(=O)[C:10](Cl)=[O:11]>ClCCCl>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([N:8]=[C:10]=[O:11])=[O:7]

Komponenten

4

Edukt 2

HCID 65578Oxalyl chlorideHCID 69108Furamide

Produkt 1

HCID 110946822-Furancarbonylisocyanate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 111,2-DichloroethaneLösungsmittel

Versuchsvorschrift

A suspension of 2-furoamide in 1,2-dichloroethane was treated with oxalyl chloride; 2-furoylisocyanate was isolated by distillation. This product was reacted with the hydroxypropylimidazole, as for the starting material of Example 12, to give 2-fluoro-4-[3-(fur-2-yl)carbamoyloxypropyl]-1-triphenylmethylimidazole, having the following n.m.r. spectrum in d6DMSO: 1.82 (m, 2H); 2.47 (t, 2H); 4.07 (t, 2H); 6.3 (s, 1H); 6.64 (m, 1H); 7.0-7.45 (m, 15H); 7.5 (m, 1H); 7.91 (m, 1H); 10.1 (br, 1H).

Quellen und Nachweise

ORD-Eintrag
ord-eaefe3b2e2564668a0197d78da36c530
Quelldatensatz
uspto-grants-1985_01
Patentnummer
US04492692

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