Methylphenidate Hydrochloride → Methylphenidate

HRID 241543

Reaktionsgleichung

Reaktionsgleichung von HRID 241543
[CH3:1][O:2][C:3]([CH:5]([CH:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:4].Cl.[OH-].[NH4+]>O>[CH3:1][O:2][C:3]([CH:5]([CH:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4]

Komponenten

4

Edukt 2

HCID 9280Methylphenidate HydrochlorideHCID 14923Ammonium Hydroxide

Produkt 1

HCID 4158MethylphenidateAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a 200 mL beaker was charged 10.0 g (37.1 mmol) racemic-methylphenidate hydrochloride and 135 mL water. About 3.39 g (96.8 mmol) ammonium hydroxide was then added to bring the pH to approximately 9 upon which an oily semi-solid formed. The product was extracted with three 100 mL portions of ethyl acetate, the combined organic layers dried over sodium sulfate, filtered and concentrated under reduced pressure at about 40° C. to provide 8.2 g of a clear, colorless viscous oil (95% yield). The IR spectrum of the oil was consistent with the intended product.

Aufarbeitung

  1. customformed
  2. extractionThe product was extracted with three 100 mL portions of ethyl acetate
  3. dry with materialthe combined organic layers dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure at about 40° C.

Quellen und Nachweise

ORD-Eintrag
ord-0c8fdbc774394d3dbb58a02c62b3cc9a
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653065B1

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