Formaldehyde → HCID 66636594, Verbindung

HRID 241705Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 241705
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[NH:7]1[CH:11]=[CH:10][CH:9]=[CH:8]1.[CH2:12]=O.[OH-].[Na+]>C(O)(=O)C>[NH:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[CH2:12][N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Komponenten

6

Edukt 4

HCID 712FormaldehydeHCID 8027PyrroleHCID 8083MorpholineHCID 14798Sodium Hydroxide

Produkt 1

HCID 66636594HCID 66636594, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a solution of morpholine (22 mmoles) in acetic acid (10 ml) there is added pyrrole (20 mmoles) dropwise at 0° C. Formaldehyde (37% aq., 20 mmoles) is then added dropwise. The reaction mixture is stirred for 2 hours at ambient temperature. The solution is cooled to 0° C. and is brought to alkaline pH (10-11) using 20% aqueous NaOH solution. After extraction with DCM, the organic phases are washed with water and with saturated aqueous NaCl solution, dried over sodium sulphate, filtered and evaporated to dryness to yield the title product in the form of a white solid which is used directly in the next Step.

Aufarbeitung

  1. temperatureThe solution is cooled to 0° C.
  2. extractionAfter extraction with DCM
  3. washthe organic phases are washed with water and with saturated aqueous NaCl solution
  4. dry with materialdried over sodium sulphate
  5. filtrationfiltered
  6. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-78a78109662945c4935ab32f178fce0f
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653073B2

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