StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

Methane → HCID 86735947, Verbindung

HRID 2419626
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 2419626
C([O:3][C:4](=[O:40])/[CH:5]=[CH:6]/[CH:7]=[CH:8]/[CH2:9][CH2:10][CH:11]([C@@H:13]1[C@:30]2([CH3:31])[C@H:16]([C@H:17]3[C@H:27]([CH2:28][C@@H:29]2[O:32]C(=O)C)[C@:25]2([CH3:26])[C@@H:20]([CH2:21][C@H:22]([O:36]C(=O)C)[CH2:23][CH2:24]2)[CH2:19][CH2:18]3)[CH2:15][CH2:14]1)[CH3:12])C.[OH-].[Na+].C>O>[OH:36][C@@H:22]1[CH2:23][CH2:24][C@@:25]2([CH3:26])[C@H:20]([CH2:19][CH2:18][C@@H:17]3[C@@H:27]2[CH2:28][C@H:29]([OH:32])[C@@:30]2([CH3:31])[C@H:16]3[CH2:15][CH2:14][C@@H:13]2[CH:11]([CH2:10]/[CH:9]=[CH:8]/[CH:7]=[CH:6]/[CH2:5][C:4]([OH:40])=[O:3])[CH3:12])[CH2:21]1
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

5

Edukt 3

HCID 297MethaneHCID 14798Sodium HydroxideHCID 86735948HCID 86735948, Verbindung

Produkt 1

HCID 86735947HCID 86735947, VerbindungAusbeute 69,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 7.25 g of 7-(3α,12α-diacetoxy-5β-pregnane-20-yl)-trans,trans-2,4-heptadienoic acid ethyl ester and 57 ml of 5N aqueous sodium hydroxide solution was stirred and refluxed for 1.5 hr. At the end of this time, 500 ml of water was added and the mixture heated to reflux. The cloudy solution was cooled, charcoal added and the mixture was filtered through a bed of diatomaceous earth. The filtrate was cooled to 0° and made acidic (pH3) by the dropwise addition of concentrated aqueous hydrochloric acid. The precipitate was filtered and air dried overnight under house vacuum. Crystallization from methyl ethyl ketone afforded 4 g of 7-(3α,12α-dihydroxy-5β-pregnane-20-yl)-trans,trans-3,5-heptadienoic acid, mp 208°-211°.

Aufarbeitung

  1. temperaturerefluxed for 1.5 hr
  2. temperaturethe mixture heated to reflux
  3. temperatureThe cloudy solution was cooled
  4. filtrationthe mixture was filtered through a bed of diatomaceous earth
  5. temperatureThe filtrate was cooled to 0°
  6. additionby the dropwise addition of concentrated aqueous hydrochloric acid
  7. filtrationThe precipitate was filtered
  8. customair dried overnight under house vacuum
  9. customCrystallization from methyl ethyl ketone

Quellen und Nachweise

ORD-Eintrag
ord-eec12f834cb84a819ae2e8a740194f50
Quelldatensatz
uspto-grants-1978_08
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04107188

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion