Methylphenidate Hydrochloride → Dexmethylphenidate

HRID 242139

Reaktionsgleichung

Reaktionsgleichung von HRID 242139
[CH3:1][O:2][C:3]([CH:5]([CH:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:4].Cl.[OH-].[NH4+]>O>[CH3:1][O:2][C:3]([C@H:5]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C@@H:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:4]

Komponenten

4

Edukt 2

HCID 9280Methylphenidate HydrochlorideHCID 14923Ammonium Hydroxide

Produkt 1

HCID 154101DexmethylphenidateAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a 200 mL beaker was charged 10.0 g (37.1 mmol) racemic-methylphenidate hydrochloride and 135 mL water. Ammonium hydroxide (3.40 g; 96.8 mmol) was then added to bring the pH to approximately 9 upon which an oily semi-solid formed. The product was extracted with three 100 mL portions of ethyl acetate, the combined organic layers were dried over sodium sulfate, filtered and concentrated under reduce pressure at 40° C. to provide 8.5 g of a clear, colorless viscous oil (98% yield). The free base was characterized by FTIR and found to be consistent with the anticipated structure

Aufarbeitung

  1. customformed
  2. extractionThe product was extracted with three 100 mL portions of ethyl acetate
  3. dry with materialthe combined organic layers were dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customat 40° C.

Quellen und Nachweise

ORD-Eintrag
ord-25c96567bb59476dbdf1d306655d996f
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653106B2

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