2-Naphthoic acid → Methyl {4-methyl-2-[4-(2-naphthoylamino)benzyl]-6-pyrrolidin-1-ylpyrimidin-5-yl}acetate

HRID 2422164

Reaktionsgleichung

Reaktionsgleichung von HRID 2422164
[CH3:1][O:2][C:3](=[O:25])[CH2:4][C:5]1[C:6]([CH3:24])=[N:7][C:8]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=2)=[N:9][C:10]=1[N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1.C1CN([P+](ON2N=NC3C=CC=CC2=3)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F.[CH:59]1[C:68]2[C:63](=[CH:64][CH:65]=[CH:66][CH:67]=2)[CH:62]=[CH:61][C:60]=1[C:69](O)=[O:70].C(N(CC)C(C)C)(C)C>C1COCC1.O>[CH3:24][C:6]1[C:5]([CH2:4][C:3]([O:2][CH3:1])=[O:25])=[C:10]([N:11]2[CH2:12][CH2:13][CH2:14][CH2:15]2)[N:9]=[C:8]([CH2:16][C:17]2[CH:18]=[CH:19][C:20]([NH:23][C:69]([C:60]3[CH:61]=[CH:62][C:63]4[C:68](=[CH:67][CH:66]=[CH:65][CH:64]=4)[CH:59]=3)=[O:70])=[CH:21][CH:22]=2)[N:7]=1

Komponenten

7

Edukt 4

HCID 71232-Naphthoic acidHCID 81531DiisopropylethylamineHCID 2724699PyBOPHCID 59514524Methyl[2-(4-aminobenzyl)-4-methyl-6-pyrrolidin-1-ylpyrimidin-5-yl]acetate

Produkt 1

HCID 59514539Methyl {4-methyl-2-[4-(2-naphthoylamino)benzyl]-6-pyrrolidin-1-ylpyrimidin-5-yl}acetateAusbeute 36,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of methyl[2-(4-aminobenzyl)-4-methyl-6-pyrrolidin-1-ylpyrimidin-5-yl]acetate (0.034 g, 0.10 mmol) in THF (1 mL) at room temperature was treated with PyBOP (0.052 g, 0.10 mmol), 2-naphthoic acid (0.019 g, 0.11 mmol), and N,N-diisopropylethylamine (0.017 mL, 0.10 mmol). After stirring at room temperature for 17 hours, the reaction mixture was poured into water and extracted with EtOAc. The combined organic extracts was dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The remaining residue was chromatographed over silica gel eluting with 60% EtOAc in CH2Cl2 to give methyl {4-methyl-2-[4-(2-naphthoylamino)benzyl]-6-pyrrolidin-1-ylpyrimidin-5-yl}acetate (0.018 g, 36% yield) as a yellow oil.

Aufarbeitung

  1. extractionextracted with EtOAc
  2. dry with materialThe combined organic extracts was dried over anhydrous MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. customThe remaining residue was chromatographed over silica gel eluting with 60% EtOAc in CH2Cl2

Quellen und Nachweise

ORD-Eintrag
ord-d80c2ccf90c94b66aad6df796da19011
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07960393B2

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