Iodoethane → 4-(1,1-Dimethylethyl)-2-ethoxy-1-iodobenzene

HRID 2425578Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2425578
[C:1]([C:5]1[CH:6]=[CH:7][C:8]([I:12])=[C:9]([OH:11])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH2:19](I)[CH3:20]>C(O)C.C(OCC)C>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([I:12])=[C:9]([O:11][CH2:19][CH3:20])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

6

Edukt 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 117478025-tert-Butyl-2-iodophenol

Produkt 1

HCID 672460864-(1,1-Dimethylethyl)-2-ethoxy-1-iodobenzeneAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

The mixture of 5-tert-butyl-2-iodo-phenol (132.7 g, 480.6 mmol), potassium carbonate (265.7 g, 1923 mmol) and ethyl iodide (76.9 mL, 961.3 mmol) in ethanol (1.125 mL) was heated at reflux overnight. Upon cooling to room temperature, the reaction mixture was diluted with diethyl ether. The white solids were filtered off, and the filtrate was concentrated in vacuo to give 4-tert-butyl-2-ethoxy-1-iodo-benzene (144.7 g) as pale yellow oil.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. filtrationThe white solids were filtered off
  4. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-73f996cd49394a1ba2d7b43b916c9472
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07964724B2

Notizen zur Reaktion

Wird geladen…