Nitrosylsulfuric acid → 4-Bromo-2-methoxy-6-methylbenzoic acid

HRID 2427489Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2427489
[Br:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6](N)=[O:7])=[C:4]([O:12][CH3:13])[CH:3]=1.N(OS(=O)(=O)O)=[O:15]>C(Cl)Cl.O>[Br:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:15])=[O:7])=[C:4]([O:12][CH3:13])[CH:3]=1

Komponenten

5

Edukt 2

HCID 82157Nitrosylsulfuric acidHCID 57949645HCID 57949645, Verbindung

Produkt 1

HCID 454803864-Bromo-2-methoxy-6-methylbenzoic acidAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

4-Bromo-2-methoxy-6-methylbenzamide (2.0 g, 8.2 mmol), dissolved in CH2Cl2, was added dropwise to nitrosyl sulfuric acid (14.0 mL) in water (6.0 mL) at 0° C. and stirred for 2 hours. The reaction mixture was poured over ice and extracted with CH2Cl2, and the solvent was removed under reduced pressure to afford a light pink solid (1.93 g, 96%). 1H NMR (300 MHz, CDCl3): δ 7.07 (s, 1H), 7.00 (s, 1H), 3.93 (s, 3H), 2.46 (s, 3H).

Aufarbeitung

  1. additionThe reaction mixture was poured over ice
  2. extractionextracted with CH2Cl2
  3. customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-275a25ad57844f80b74d5fa2acd944ae
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07968570B2

Notizen zur Reaktion

Wird geladen…