Hydrochloric Acid → Zantac

HRID 24286

Reaktionsgleichung

Reaktionsgleichung von HRID 24286
[CH3:1][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15]([NH:20][CH3:21])=[CH:16][N+:17]([O-:19])=[O:18])=[CH:7][CH:6]=1)[CH3:3].[ClH:22].O>C(OCC)(=O)C.C(O)(C)C>[ClH:22].[CH3:3][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15]([NH:20][CH3:21])=[CH:16][N+:17]([O-:19])=[O:18])=[CH:7][CH:6]=1)[CH3:1]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 5039Ranisen

Produkt 1

HCID 47909Zantac

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3776IsopropanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Suspend 10.0 g of Z, N-[2-[[[5-(dimethylamino)methyl-2-furanyl] methyl]thio]ethyl]-N′-methyl-2-nitro-1,1-ethenediamine in 100 ml of ethyl acetate. Add dropwise to the mixture 21.95 g of hydrochloric acid (concentration 5.29% mol/mol) in isopropanol, to which the 3% of distilled water was previously added, during 45 minutes, keeping the temperature at 25° C. Stirring vigorously, a white precipitate is obtained. Wash and filter the precipitate with a mixture of ethyl acetate/isopropanol in 80:20 ratio and later with ethyl acetate alone.

Aufarbeitung

  1. additionwas previously added, during 45 minutes
  2. customat 25° C
  3. customa white precipitate is obtained
  4. washWash
  5. filtrationfilter the precipitate
  6. additionwith a mixture of ethyl acetate/isopropanol in 80:20 ratio

Quellen und Nachweise

ORD-Eintrag
ord-befcdfda4f1a48f193b3ca7e1d82296d
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06855835B2

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