5-Fluoroisatin → 5-fluoro-1,3-dihydro-2H-indol-2-one

HRID 24307

Reaktionsgleichung

Reaktionsgleichung von HRID 24307
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=O>O.NN>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2

Komponenten

3

Edukt 1

HCID 2365665-Fluoroisatin

Produkt 1

HCID 37310125-fluoro-1,3-dihydro-2H-indol-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24654Hydrazine hydrate (1:1)Lösungsmittel

Versuchsvorschrift

5-Fluoroisatin (8.2 g) was dissolved in 50 mL of hydrazine hydrate and refluxed for 1.0 hr. The reaction mixtures were then poured in ice water. The precipitate was then filtered, washed with water and dried in a vacuum oven to afford the title compound.

Aufarbeitung

  1. temperaturerefluxed for 1.0 hr
  2. customThe reaction mixtures
  3. filtrationThe precipitate was then filtered
  4. washwashed with water
  5. customdried in a vacuum oven

Quellen und Nachweise

ORD-Eintrag
ord-85f8d0a13c1741908216e141c66ffd9d
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06855730B2

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