Acetic Acid → 7-Azaoxindole acetic acid salt

HRID 24401Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 24401
Br[C:2]1(Br)[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]1=[O:11].[C:13]([OH:16])(=[O:15])[CH3:14]>C(#N)C.[Zn]>[C:13]([OH:16])(=[O:15])[CH3:14].[NH:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][N:6]=2)[CH2:2][C:3]1=[O:11]

Komponenten

5

Edukt 2

HCID 176Acetic AcidHCID 138640943,3-Dibromo-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

Produkt 1

HCID 219257347-Azaoxindole acetic acid saltAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23994ZincKatalysatorHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Zinc dust (6.5 g) was added to a solution of 3,3-dibromo-7-azaoxindole (2.9 g) in acetic acid (20 ml) and acetonitrile (30 ml). The mixture was stirred for 2 hours at room temperature. The solids were removed by filtration and the solvent evaporated. The residue was treated with ethyl acetate. The ethyl acetate solution containing insoluble solid was passed through a short column of silica gel. The collected ethyl acetate solution was evaporated and the residue dried under vacuum to give 1.8 g (91% yield) of 7-aza-2-oxindole acetic acid salt.

Aufarbeitung

  1. customThe solids were removed by filtration
  2. customthe solvent evaporated
  3. additionThe residue was treated with ethyl acetate
  4. additionThe ethyl acetate solution containing insoluble solid
  5. customThe collected ethyl acetate solution was evaporated
  6. customthe residue dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-72dacf05edc84f9095ba6d710f037b89
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06855730B2

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