Hydrazine hydrate (1:1) → 4-Iodo-1H-pyrazolo[3,4-b]pyridine

HRID 244692Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 244692
F[C:2]1[C:7]([CH:8]=O)=[C:6]([I:10])[CH:5]=[CH:4][N:3]=1.O.[NH2:12][NH2:13]>O>[I:10][C:6]1[CH:5]=[CH:4][N:3]=[C:2]2[NH:12][N:13]=[CH:8][C:7]=12

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 99923282-Fluoro-4-iodopyridine-3-carbaldehyde

Produkt 1

HCID 576428014-Iodo-1H-pyrazolo[3,4-b]pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

2-Fluoro-4-iodo-3-pyridinecarbaldehyde (from Asymchem) (0.97 g) was added portionwise over 5 min to hydrazine hydrate (5 ml). The resulting suspension was stirred at room temperature for 5 h. Water (10 ml) was added and the solid was filtered and washed with further water to give title compound, 664 mg.

Aufarbeitung

  1. filtrationthe solid was filtered
  2. washwashed with further water

Quellen und Nachweise

ORD-Eintrag
ord-368915bb429a4681afba7d3f42f61558
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658635B2

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