Water → Furan-2-acetic acid

HRID 244959

Reaktionsgleichung

Reaktionsgleichung von HRID 244959
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]#N.[OH-:9].[K+].[OH2:11]>C(OCC)C>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([OH:11])=[O:9]

Komponenten

5

Edukt 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 109095152-Furanacetonitrile

Produkt 1

HCID 75974Furan-2-acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

2-(Furan-2-yl)acetonitrile was suspended in 300 mL of distilled water, mixed with 50 g (0.89 mmol) of potassium hydroxide and heated for 4 hours under reflux. After completion of the reaction, the reaction solution was diluted with diethyl ether and separated. The resulting aqueous layer was acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and filterd, and the filtrate was concentrated under reduced pressure to give 25.2 g of the desired product.

Aufarbeitung

  1. temperatureheated for 4 hours
  2. temperatureunder reflux
  3. customAfter completion of the reaction
  4. customseparated
  5. extractionextracted with ethyl acetate
  6. washThe organic layer was washed with saturated aqueous sodium chloride
  7. dry with materialdried over anhydrous magnesium sulfate and filterd
  8. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8ad6f5e198e443a5a0b4fe2b8f1ab697
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658686B2

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