Sodium Hydroxide → HCID 178433474, Verbindung

HRID 247267Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 247267
[OH-].[Na+].[OH:3][C:4]1[N:12]=[C:11]([CH3:13])[CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7].[Cl:14][O-].[Na+]>O>[Cl:14][C:10]1[CH:9]=[C:5]([C:6]([OH:8])=[O:7])[C:4]([OH:3])=[N:12][C:11]=1[CH3:13]

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 23665760Sodium HypochloriteHCID 178425908HCID 178425908, Verbindung

Produkt 1

HCID 178433474HCID 178433474, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 15.7 g of 50% sodium hydroxide and 18.2 ml of water was added 10 g (0.065 mole) of 2-hydroxy-6-methylnicotinic acid. When the acid had dissolved, 200 ml of 5.25% aqueous sodium hypochlorite was added rapidly through a dropping funnel. The temperature was not moderated (slight exotherm did occur). The entire mixture was stirred at room temperature for 18 hr. The reaction mixture was then filtered and acidified with concentrated hydrochloric acid. The precipitate was recrystallized from isopropyl alcohol/ethereal to give ~6 g of analytically pure crystals, m.p. 291°-94° C.

Aufarbeitung

  1. dissolutionWhen the acid had dissolved
  2. filtrationThe reaction mixture was then filtered
  3. customThe precipitate was recrystallized from isopropyl alcohol/ethereal
  4. customto give ~6 g of analytically pure crystals, m.p. 291°-94° C.

Quellen und Nachweise

ORD-Eintrag
ord-608af73f5b864975b54fddea2afedb6a
Quelldatensatz
uspto-grants-1987_11
Patentnummer
US04705853

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