Phenacylamine → 2-Aminoacetophenone 4-chlorophenylhydrazone

HRID 249317Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 249317
[NH2:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][NH2:19])=[CH:14][CH:13]=1>CCO.CC(O)=O.O>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][N:19]=[C:3]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:2][NH2:1])=[CH:14][CH:13]=1

Komponenten

6

Edukt 2

HCID 11952PhenacylamineHCID 70624(4-Chlorophenyl)hydrazine

Produkt 1

HCID 867463512-Aminoacetophenone 4-chlorophenylhydrazoneAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 176Acetic AcidLösungsmittelHCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 10.43 g 2-aminoacetophenone and 11.0 g 4-chlorophenylhydrazine in 30 ml EtOH and 10 ml HOAc was refluxed for one hour. The cooled reaction mixture was diluted with water and the precipitate was collected, washed with water, and dried to give 16.83 g solid. Recrystallization from methanol gave 3.48 g solid, m.p. 109°-112° C.

Aufarbeitung

  1. temperaturewas refluxed for one hour
  2. customThe cooled reaction mixture
  3. customthe precipitate was collected
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-fd729e02bed74f7e97efb42406945fc6
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05214059

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