Lithium hydroxide, monohydrate → Lithium 2-thioxo-2,3-dihydrobenzoxazole-4-carboxylate

HRID 249863

Reaktionsgleichung

Reaktionsgleichung von HRID 249863
[S:1]=[C:2]1[NH:6][C:5]2=[C:7]([C:11]([O:13]C)=[O:12])[CH:8]=[CH:9][CH:10]=[C:4]2[O:3]1.O.[OH-].[Li+:17]>C1COCC1.O>[S:1]=[C:2]1[NH:6][C:5]2=[C:7]([C:11]([O-:13])=[O:12])[CH:8]=[CH:9][CH:10]=[C:4]2[O:3]1.[Li+:17]

Komponenten

5

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 22272869Methyl 2-thioxo-2,3-dihydrobenzoxazole-4-carboxylate

Produkt 1

HCID 86623720Lithium 2-thioxo-2,3-dihydrobenzoxazole-4-carboxylateAusbeute 96,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

To a solution of methyl 2-thioxo-2,3-dihydrobenzoxazole-4-carboxylate (150 mg, 0.72 mmol) in THF (6 mL) was added a solution of lithium hydroxide monohydrate (45.1 mg, 1.08 mmol) in H2O (3 mL). The reaction mixture was heated to 75° C. with stirring for 3 days, cooled down to room temperature and concentrated under reduced pressure to afford the lithium 2-thioxo-2,3-dihydrobenzoxazole-4-carboxylate (135 mg, 96.5%) as a yellow solid. MS consistent

Aufarbeitung

  1. temperaturecooled down to room temperature
  2. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-594f69d80b204df6a9ebf4a3bc0545bc
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07863271B2

Verknüpfte Notizen

Wird geladen…