Water → Benzenemethanol,2-fluoro-,1-methansulfonate

To a solution of 2-Fluorobenzyl alcohol (10 g, 79.28 mmol) in dry dichloromethane (200 ml) was added triethylamine (12.03 g, 118.9 mmol) under argon at room temperature. Methanesulfonyl chloride (10.71 g, 93.5 mmol) was added to the above reaction mixture of 0° C., and stirring was continued for another 3 hours. Water (100 ml) was added to the reaction mixture and the mixture was extracted twice with dichloromethane. The combined organic layers were washed with water and brine. The reaction mixture was dried over Na2SO4, filtered and concentrated to give the title compound as an yellow oil which was used without further purification.

1. extractionthe mixture was extracted twice with dichloromethane
2. washThe combined organic layers were washed with water and brine
3. dry with materialThe reaction mixture was dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated

ORD-Eintrag

ord-d2f54d8cf369460c8e6217de1054e9b8

Quelldatensatz

uspto-grants-2005_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06858602B2