Methanol → HCID 66713064, Verbindung

HRID 250445Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 250445
[CH3:1][O:2][C:3](=[O:25])[CH2:4][NH:5][C:6]([C:8]1[N:9]=[C:10](Cl)[C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:7].C([O-])(=O)C.[Na+].CO>[Pd].CCOC(C)=O>[CH3:1][O:2][C:3](=[O:25])[CH2:4][NH:5][C:6]([C:8]1[N:9]=[CH:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:7]

Komponenten

6

Edukt 3

HCID 887MethanolHCID 517045Sodium AcetateHCID 86014604HCID 86014604, Verbindung

Produkt 1

HCID 66713064HCID 66713064, VerbindungAusbeute 96,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of [(1-chloro-4-phenyl-isoquinoline-3-carbonyl)-amino]-acetic acid methyl ester (177 mg, 0.5 mmol, Example D-74 b), Pd/C (50 mg, 10 wt % Pd), sodium acetate (49 mg, 0.6 mmol), MeOH (10 ml) and EtOAc (5 ml) was stirred under a H2-atmosphere at ambient pressure and temperature for 2 h. Then the mixture was filtered through a pad of celite. Celite and filter cake were washed thoroughly with EtOAc and the combined organic phases were concentrated in vacuo. To the residue was added concentrated aqueous NaHCO3 (10 ml) and the mixture was extracted with EtOAc (2×15 ml). The combined organic phases were dried over MgSO4 and concentrated in vacuo to give the title compound as a colorless gum (154 mg); MS-(+)-ion: M+1=321.0.

Aufarbeitung

  1. filtrationThen the mixture was filtered through a pad of celite
  2. filtrationCelite and filter cake
  3. washwere washed thoroughly with EtOAc
  4. concentrationthe combined organic phases were concentrated in vacuo
  5. additionTo the residue was added concentrated aqueous NaHCO3 (10 ml)
  6. extractionthe mixture was extracted with EtOAc (2×15 ml)
  7. dry with materialThe combined organic phases were dried over MgSO4
  8. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-db0f92b216554f5f8af7b22f061c78b4
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07863292B2

Notizen zur Reaktion

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