Water → Benzenemethanol,2-fluoro-,1-methansulfonate

To a solution of 2-Fluorobenzyl alcohol (10 g, 79.28 mmol) in dry dichloromethane (200 ml) was added triethylamine (12.03 g, 118.9 mmol) under argon at room temperature. Methanesulfonyl chloride (10.71 g, 93.5 mmol) was added to the above reaction mixture at 0° C., and stirring was continued for another 3 hours. Water (100 ml) was added to the reaction mixture and the mixture was extracted twice with dichloromethane. The combined organic layers were washed with water and brine. The reaction mixture was dried over Na2SO4, filtered and concentrated to give the title compound as an yellow oil which was used without further purification.

1. extractionthe mixture was extracted twice with dichloromethane
2. washThe combined organic layers were washed with water and brine
3. dry with materialThe reaction mixture was dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated

ORD-Eintrag

ord-ac9c104d50c64a42a0dc985d41799f00

Quelldatensatz

uspto-grants-2011_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07863475B2