Ethanol → 5-Amino-1-(2-chloro-6-ethoxy-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole

HRID 253525

Reaktionsgleichung

Reaktionsgleichung von HRID 253525
[NH2:1][C:2]1[N:6]([C:7]2C(Cl)=C[C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]#[N:20])[C:3]=1[S:21][C:22]([F:25])([F:24])[F:23].C(O)C.CC(C)([O-])C.[Na+].CCCCCCC.[C:42]([O:45][CH2:46][CH3:47])(=O)[CH3:43]>CN(C)C=O.[Cu]Br.O>[NH2:1][C:2]1[N:6]([C:7]2[C:42]([O:45][CH2:46][CH3:47])=[CH:43][C:10]([C:14]([F:15])([F:16])[F:17])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]#[N:20])[C:3]=1[S:21][C:22]([F:25])([F:24])[F:23]

Komponenten

8

Edukt 4

HCID 702EthanolHCID 9953940Fipronil sulfideHCID 21899848Ethylacetate heptaneHCID 23676156Sodium t-butoxide

Produkt 1

HCID 114190085-Amino-1-(2-chloro-6-ethoxy-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 24593copper(I) bromideKatalysatorHCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a mixture of 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole (4.5 g, 10.7 mmol) and ethanol (0.73 g, 16.0 mmol) in N,N-dimethylformamide (25 ml), was added sodium tert-butoxide (1.54 g, 16.0 mmol) and copper(I)bromide (0.08 g, 0.5 mmol). The mixture was heated at 90° C. for 7 hours under nitrogen. After extractive workup (heptane-ethyl acetate, water) and column chromatography the title product was obtained (2.17 g), mp 166° C., 1H-NMR: 1.34 (3H), 4.14 (2H), 4.35 (2H), 7.20 and 7.45; 19F-NMR: −45.2, −63.9.

Quellen und Nachweise

ORD-Eintrag
ord-25d93cffb5214c8f898fd5d5e569c14d
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07872038B2

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