Water → 2,1,3-Benzothiadiazol-5-amine

HRID 254989Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 254989
O.[N+:2]([C:5]1[CH:13]=[CH:12][C:8]2=[N:9][S:10][N:11]=[C:7]2[CH:6]=1)([O-])=O>C1COCC1.[Zn]>[N:9]1[S:10][N:11]=[C:7]2[CH:6]=[C:5]([NH2:2])[CH:13]=[CH:12][C:8]=12

Komponenten

5

Edukt 2

HCID 962WaterHCID 2978975-Nitro-2,1,3-benzothiadiazole

Produkt 1

HCID 3143132,1,3-Benzothiadiazol-5-amineAusbeute 47,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23994ZincKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a suspension of MoCl5 (8 g) in 50 ml of THF was added 10 ml of H2O and followed by the addition of Zn dust (3 g) 5 minutes later. 5-Nitrobenzo-2,1,3-thiadiazole (1.0 g) was then added to this mixture and the resulting reaction mixture was kept under reflux for 20 minutes. Benzo[1,2,5]thiadiazol-5-ylamine (0.4 g) was isolated by filtration and purified by column chromatography to be used in the next step.

Aufarbeitung

  1. customthe resulting reaction mixture
  2. temperatureunder reflux for 20 minutes

Quellen und Nachweise

ORD-Eintrag
ord-90d1ab0d08e848c7ad5d08aef55c54b7
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07875728B2

Notizen zur Reaktion

Wird geladen…