Hydrochloric Acid → 83406-09-1

HRID 255152

Reaktionsgleichung

Reaktionsgleichung von HRID 255152
[OH-:1].[K+].[Mn]([O-])(=O)(=O)=O.[K+].Br[C:10]12[CH2:19][CH:14]3[CH2:15][CH:16]([CH2:18][C:12]([C:20]([OH:22])=[O:21])([CH2:13]3)[CH2:11]1)[CH2:17]2.Cl.S(=O)(O)[O-:25].[Na+]>O>[OH:1][C:14]12[CH2:15][CH:16]3[CH2:17][C:10]([OH:25])([CH2:11][C:12]([C:20]([OH:22])=[O:21])([CH2:18]3)[CH2:13]1)[CH2:19]2

Komponenten

7

Edukt 5

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 308183-Bromoadamantane-1-carboxylic acidHCID 516875Potassium PermanganateHCID 23665763Sodium Bisulfite

Produkt 1

HCID 1201064783406-09-1

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
98 °C

Versuchsvorschrift

To a mixture of potassium hydroxide (130 mg, 2.0 mmol) and potassium permanganate (350 mg, 2.2 mmol) in H2O (10 mL) at 50° C. was added 3-bromo-adamantane-1-carboxylic acid (512 mg, 2.0 mmol). The reaction mixture was heated at 98° C. for 18 hours. After cooling to ambient temperature, the mixture was acidified by the addition of 6 N aqueous HCl, then saturated aqueous sodium bisulfite was added. The mixture was extracted with 2-propanol/CH2Cl2 (1:3). The organic extract was concentrated to afford the title compound.

Aufarbeitung

  1. temperatureAfter cooling to ambient temperature
  2. extractionThe mixture was extracted with 2-propanol/CH2Cl2 (1:3)
  3. extractionThe organic extract
  4. concentrationwas concentrated

Quellen und Nachweise

ORD-Eintrag
ord-72a5d0db12b2499896568952461b4c0c
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07875639B2

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