Dimethylformamide → 3-(2-Methyl-thiazol-4-yl)-phenylamine

HRID 255900

Reaktionsgleichung

Reaktionsgleichung von HRID 255900
Br.[NH2:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6](=O)[CH2:7]Br.[C:13]([NH2:16])(=[S:15])[CH3:14].CN(C)C=O.[OH-].[Na+]>O>[CH3:14][C:13]1[S:15][CH:7]=[C:6]([C:5]2[CH:10]=[CH:11][CH:12]=[C:3]([NH2:2])[CH:4]=2)[N:16]=1

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 14798Sodium HydroxideHCID 2723949ThioacetamideHCID 201651043-Amino-phenacyl bromide hydrobromide

Produkt 1

HCID 7365353-(2-Methyl-thiazol-4-yl)-phenylamineAusbeute 79 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 3-amino-phenacyl bromide hydrobromide (11.78 g), thioacetamide (3 g) and dimethylformamide (20 ml) was stirred at room temperature for 24 hours and then poured into water (100 ml). The resulting solution was made alkaline with 10% sodium hydroxide, and the precipitate was filtered off and dried to give 6 g of 2-methyl-4-(3-amino-phenyl)-thiazole; M.p. 134°-137° C.

Aufarbeitung

  1. filtrationthe precipitate was filtered off
  2. customdried

Quellen und Nachweise

ORD-Eintrag
ord-6884dac1deb44f1293e4f4875b0ec887
Quelldatensatz
uspto-grants-1987_10
Patentnummer
US04699915

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