Allyl chloride → 4,7-Methano-1H-inden-5-ol, octahydro-5-(2-propen-1-yl)-

HRID 25880

Reaktionsgleichung

Reaktionsgleichung von HRID 25880
[Mg].O1C[CH2:5][CH2:4][CH2:3]1.C(Cl)C=C.[CH:11]12[CH2:21][CH:17]([C:18](=[O:20])[CH2:19]1)[CH:16]1[CH:12]2[CH2:13][CH2:14][CH2:15]1>C(O)(=O)C>[CH2:5]([C:18]1([OH:20])[CH2:19][CH:11]2[CH2:21][CH:17]1[CH:16]1[CH:12]2[CH2:13][CH2:14][CH2:15]1)[CH:4]=[CH2:3]

Komponenten

6

Edukt 4

HCID 7850Allyl chloride2×HCID 8028Tetrahydrofuran2×HCID 965094,7-Methano-5H-inden-5-one, octahydro-HCID 5462224Magnesium

Produkt 1

HCID 1084644,7-Methano-1H-inden-5-ol, octahydro-5-(2-propen-1-yl)-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

In a one litre reaction vessel, equipped with a stirrer, a cooler and a dropping funnel, 26.4 g magnesium, 100 g tetrahydrofurane and 1 g allyl chloride were heated to about 40° C. to start the reaction. A mixture of 76.5 g allyl chloride, 250 g tetrahydrofurane and 150 g tricyclo [5,2,1,02,6 ] decan-8-one was added in four hours, keeping the temperature at 35°-40° C. The reaction mixture was stirred for an additional 30 minutes and subsequently poured into a mixture of 600 g of ice and 80 g of acetic acid. The layers were separated and the water layer extracted twice with toluene. The combined organic layers were washed with 5% soda solution until alkaline and subsequently with water until neutral. The organic solvent was removed by distillation under reduced pressure. The residue was distilled on a Vigreux head at 2 mm.Hg. The fraction boiling between 93° and 95° C. was collected.

Aufarbeitung

  1. customIn a one litre reaction vessel
  2. customequipped with a stirrer
  3. customthe reaction
  4. additionwas added in four hours
  5. customat 35°-40° C
  6. customThe layers were separated
  7. extractionthe water layer extracted twice with toluene
  8. washThe combined organic layers were washed with 5% soda solution until alkaline and subsequently with water until neutral
  9. customThe organic solvent was removed by distillation under reduced pressure
  10. distillationThe residue was distilled on a Vigreux head at 2 mm.Hg
  11. customboiling between 93° and 95° C.
  12. customwas collected

Quellen und Nachweise

ORD-Eintrag
ord-5fabb5e76e014b6c8c60849dd122a97a
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04147671

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