Tetrahydrofuran → Maltol

HRID 25905

Reaktionsgleichung

Reaktionsgleichung von HRID 25905
[O:1]1CCCC1.BrBr.[O:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[CH:13]([OH:15])[CH3:14]>O>[CH3:14][C:13]1[O:15][CH:12]=[CH:11][C:10](=[O:1])[C:9]=1[OH:8]

Komponenten

5

Edukt 3

HCID 8028TetrahydrofuranHCID 24408BromineHCID 1072431-(2-Furyl)ethanol

Produkt 1

HCID 8369MaltolAusbeute 53 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

To a 4-neck round bottom flask equipped with a thermometer, a condensor and two addition funnels was charged 50 ml of tetrahydrofuran and 50 ml of water and the solution was cooled to 10° C. To this well stirred solution was added together in the two addition funnels bromine (0.20 mole) and 1(2-furyl)-1-ethanol (0.09 mole). The temperature of the reaction was maintained at 15° C. throughout the double addition. The reaction mixture was then heated to 75° C. for 10 hours. Maltol was isolated by the procedure of Example 1 (53% yield).

Aufarbeitung

  1. customTo a 4-neck round bottom flask equipped with a thermometer
  2. additiona condensor and two addition funnels
  3. temperatureThe temperature of the reaction was maintained at 15° C. throughout the double addition
  4. temperatureThe reaction mixture was then heated to 75° C. for 10 hours

Quellen und Nachweise

ORD-Eintrag
ord-86108ece6be54748bf031644ae43cd30
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04147705

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