Water → 2-Fluoro-5-methoxybenzoic acid

HRID 259933

Reaktionsgleichung

Reaktionsgleichung von HRID 259933
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[CH3:10].[Mn]([O-])(=O)(=O)=[O:12].[K+].[OH2:17]>N1C=CC=CC=1>[F:1][C:2]1[C:3]([C:10]([OH:12])=[O:17])=[CH:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 1375464-Fluoro-3-methylanisoleHCID 516875Potassium Permanganate

Produkt 1

HCID 27745432-Fluoro-5-methoxybenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

4-Fluoro-3-methylanisol (1.0 g, 7.1 mmol) was dissolved in a mixture of pyridine (16 mL) and water (32 mL). Potassium permanganate (3.4 g, 21 mmol) was added and the reaction mixture was refluxed for 3 h and then left at room temperature over night. After filtration and extraction with CH2Cl2 the aqueous phase was acidified with HCl precipitating the product (440 mg).

Aufarbeitung

  1. temperaturethe reaction mixture was refluxed for 3 h
  2. waitleft at room temperature over night
  3. filtrationAfter filtration and extraction with CH2Cl2 the aqueous phase

Quellen und Nachweise

ORD-Eintrag
ord-467aaa5bc85d4a349ff0c6b06ef72370
Quelldatensatz
uspto-grants-1996_06
Patentnummer
US05523475

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