Diethyl Ether → 2,2-Dimethylhexan-1-amine

HRID 26008

Reaktionsgleichung

Reaktionsgleichung von HRID 26008
[CH3:1][C:2]([CH3:9])([CH2:5][CH2:6][CH2:7][CH3:8])[C:3]#[N:4].CCOCC.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O>[CH3:1][C:2]([CH3:9])([CH2:5][CH2:6][CH2:7][CH3:8])[CH2:3][NH2:4]

Komponenten

6

Edukt 4

HCID 3283Diethyl Ether2×HCID 14798Sodium HydroxideHCID 35735622,2-DimethylhexanenitrileHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 543253312,2-Dimethylhexan-1-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

A solution of 2,2-dimethylcapronitrile (10.0 g., 0.078 mole) in 100 ml. of ether is added slowly to a suspension of lithium aluminum hydride (6.0 g., 0.158 mole) in 200 ml. of ether while maintaining the reaction at 0°-5°. After stirring the reaction mixture for an additional 2 hr., at 0.5°, the mixture is hydrolyzed by sequentially adding 6.0 ml. of water, 6.0 ml. of 15% sodium hydroxide solution, and finally 18 ml. of water. The hydrolyzed mixture is stirred for an additional hour, filtered and the ether phase concentrated under reduced pressure. Distillation of residual material provides 2,2-dimethylhex-1-ylamine.

Aufarbeitung

  1. customthe reaction at 0°-5°
  2. customat 0.5°
  3. additionby sequentially adding 6.0 ml
  4. stirringThe hydrolyzed mixture is stirred for an additional hour
  5. filtrationfiltered
  6. concentrationthe ether phase concentrated under reduced pressure
  7. distillationDistillation of residual material

Quellen und Nachweise

ORD-Eintrag
ord-eeed12b3af744259bd76c2d7e4263f32
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04147805

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