2,6-Dimethylaniline → N-(2,6-Dimethylphenyl)butanamide

HRID 26019

Reaktionsgleichung

Reaktionsgleichung von HRID 26019
[CH3:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:3]=1[NH2:4].[C:10](Cl)(=[O:14])[CH2:11][CH2:12][CH3:13]>CCOCC>[C:10]([NH:4][C:3]1[C:5]([CH3:9])=[CH:6][CH:7]=[CH:8][C:2]=1[CH3:1])(=[O:14])[CH2:11][CH2:12][CH3:13]

Komponenten

4

Edukt 2

HCID 68962,6-DimethylanilineHCID 8855Butyryl chloride

Produkt 1

HCID 36333N-(2,6-Dimethylphenyl)butanamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A solution of 200 g. of 2,6-dimethylaniline in 2 l. of ether is cooled in an ice bath and to this 88 g. of butyryl chloride in 150 ml. of ether is added dropwise (over 21/2 hours). A white precipitate forms and the reaction mixture is allowed to stir at 0° C. for 1 hour longer and then 15 hours at room temperature. The reaction mixture is then evaporated in vacuo and the white solid residue is slurried in 1 l. of water, filtered and washed with water and dried to obtain N-butyryl-2,6-dimethylaniline (m.p. 134°-6° C.).

Aufarbeitung

  1. custom15 hours
  2. customat room temperature
  3. customThe reaction mixture is then evaporated in vacuo
  4. filtrationof water, filtered
  5. washwashed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-fe2f49829bb547db92b30e430a8ae25b
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04147804

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