Boc-Gly-Gly-Ala-Pro-OBzl → Boc-Gly-Gly-Ala-Pro-OH

HRID 260250Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 260250
[NH:1]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[CH2:2][C:3]([NH:5][CH2:6][C:7]([NH:9][C@H:10]([C:12]([N:14]1[CH2:28][CH2:27][CH2:26][C@H:15]1[C:16]([O:18]CC1C=CC=CC=1)=[O:17])=[O:13])[CH3:11])=[O:8])=[O:4]>C(O)(=O)C.[Pd]>[NH:1]([C:29]([O:31][C:32]([CH3:33])([CH3:35])[CH3:34])=[O:30])[CH2:2][C:3]([NH:5][CH2:6][C:7]([NH:9][C@H:10]([C:12]([N:14]1[CH2:28][CH2:27][CH2:26][C@H:15]1[C:16]([OH:18])=[O:17])=[O:13])[CH3:11])=[O:8])=[O:4]

Komponenten

4

Edukt 1

HCID 131719402Boc-Gly-Gly-Ala-Pro-OBzl

Produkt 1

HCID 53321812Boc-Gly-Gly-Ala-Pro-OH

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Boc-Gly-Gly-Ala-Pro-OBzl (30.0 g, 0.061 mole) was dissolved in glacial acetic acid (300 mL) and 3.0 g of 10% Palladium on activated charcoal was added. This mixture was hydrogenated at 40 psi for 6 h. The reaction mixture was filtered through celite and the solvent was removed in vacuum. The resulting residue was triturated with ether, faltered, washed with ether, and dried to obtain Boc-Gly-Gly-Ala-Pro-OH.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through celite
  2. customthe solvent was removed in vacuum
  3. customThe resulting residue was triturated with ether
  4. washwashed with ether
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ba75f07f17344df7bdaa8bafc0bdb6dc
Quelldatensatz
uspto-grants-1996_06
Patentnummer
US05527610

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