2-Methoxyisonicotinonitrile → (2-Methoxypyridin-4-yl)methanamine

HRID 260472

Reaktionsgleichung

Reaktionsgleichung von HRID 260472
[C:1]([C:3]1[CH:8]=[CH:7][N:6]=[C:5]([O:9][CH3:10])[CH:4]=1)#[N:2]>C(O)C.[Pd]>[NH2:2][CH2:1][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([O:9][CH3:10])[CH:4]=1

Komponenten

4

Edukt 1

HCID 72048872-Methoxyisonicotinonitrile

Produkt 1

HCID 16227983(2-Methoxypyridin-4-yl)methanamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 4-cyano-2-methoxypyridine (0.55 g, 4.1 mmol) in ethanol was hydrogenated at 60 psi H2 in the presence of 10% Pd/C (100 mg). After 3.5 h the catalyst was removed by filtration through Super-Gel and the liltrate evaporated to give the title compound as a foam.

Aufarbeitung

  1. customAfter 3.5 h the catalyst was removed by filtration through Super-Gel
  2. customthe liltrate evaporated

Quellen und Nachweise

ORD-Eintrag
ord-3fa0020c6e9c4e56a9b2fcba963c000d
Quelldatensatz
uspto-grants-1996_06
Patentnummer
US05527819

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