Acetic Acid → N-(4-piperidyl)-4-(N-acetyl-N-methylamino)benzenesulfonamide acetate

HRID 260886

Reaktionsgleichung

Reaktionsgleichung von HRID 260886
[C:1]([N:4]([C:6]1[CH:11]=[CH:10][C:9]([S:12](Cl)(=[O:14])=[O:13])=[CH:8][CH:7]=1)[CH3:5])(=[O:3])[CH3:2].[NH2:16][CH:17]1[CH2:22][CH2:21][N:20]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:19][CH2:18]1.[C:30]([OH:33])(=[O:32])[CH3:31].[H][H]>C(O)C.[Pd]>[CH2:23]([N:20]1[CH2:21][CH2:22][CH:17]([NH:16][S:12]([C:9]2[CH:10]=[CH:11][C:6]([N:4]([C:1](=[O:3])[CH3:2])[CH3:5])=[CH:7][CH:8]=2)(=[O:14])=[O:13])[CH2:18][CH2:19]1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1.[C:30]([OH:33])(=[O:32])[CH3:31].[NH:20]1[CH2:21][CH2:22][CH:17]([NH:16][S:12]([C:9]2[CH:10]=[CH:11][C:6]([N:4]([C:1](=[O:3])[CH3:2])[CH3:5])=[CH:7][CH:8]=2)(=[O:14])=[O:13])[CH2:18][CH2:19]1

Komponenten

8

Edukt 4

HCID 176Acetic AcidHCID 2931464-(N-methylacetamido)benzene-1-sulfonyl chlorideHCID 4158521-Benzyl-4-piperidylamineHCID 178418361HCID 178418361, Verbindung

Produkt 2

HCID 15049722N-(1-Benzyl-4-piperidyl)-4-(N-acetyl-N-methylamino)benzenesulfonamideHCID 67690431N-(4-piperidyl)-4-(N-acetyl-N-methylamino)benzenesulfonamide acetateAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

N-(1-Benzyl-4-piperidyl)-4-(N-acetyl-N-methylamino)benzenesulfonamide was prepared as a colorless oil from the 4-(N-acetyl-N-methylamino)benzenesulfonyl chloride (20.0 g, 80.8 mmol) and 4-amino-1-benzylpiperidine (18.16 ml, 88.9 mmol) in a similar manner to that described in Preparative Example 16. This oil was dissolved in ethanol (200 ml), followed by the addition of glacial acetic acid (10.0 ml). The obtained mixture was stirred in the presence of 10% palladium/carbon (water-containing one, 2.00 g) in a hydrogen atmosphere (1 atm) at 50° C. for 5 hours and filtered to remove the catalyst. The filtrate was concentrated to precipitate a crystal. The resulting mixture was washed with ethyl acetate and filtered to give the title compound as a white crystal (29.70 g, overall yield of two steps: 100%).

Aufarbeitung

  1. filtrationfiltered
  2. customto remove the catalyst
  3. concentrationThe filtrate was concentrated
  4. customto precipitate a crystal
  5. washThe resulting mixture was washed with ethyl acetate
  6. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-61daeb8a02174afeb1a6871e64eb89aa
Quelldatensatz
uspto-grants-1996_06
Patentnummer
US05530118

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