Hydrochloric Acid → 2-Ethyl-2-methyl-indan

HRID 261529

Reaktionsgleichung

Reaktionsgleichung von HRID 261529
Cl.[CH2:2]([C:4]1([CH3:14])[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]1=O)[CH3:3]>O.C(O)C.[Zn].C([O-])(=O)C.[Hg+2].C([O-])(=O)C>[CH2:2]([C:4]1([CH3:14])[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5]1)[CH3:3]

Komponenten

7

Edukt 2

HCID 313Hydrochloric AcidHCID 146860942-Ethyl-2-methyl-1-indanone

Produkt 1

HCID 203944402-Ethyl-2-methyl-indan

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 15337Mercuric acetateKatalysatorHCID 23994ZincKatalysatorHCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

335 g of zinc dust and 33.5 g of mercury (II) acetate and a solution of 330 cc of concentrated hydrochloric acid in 280 cc of water are rapidly added dropwise in a stirring apparatus. The mixture is boiled at reflux and a solution of 63 g of 2-ethyl-2-methyl-1-indanone in 525 cc of ethanol is added dropwise within 10 minutes while stirring. The reaction mixture is subsequently stirred at reflux for 28 hours, cooled, filtered, and the residue is washed with water/petroleum ether. The filtrate is extracted with petroleum ether, the petroleum ether extract is washed with water and dried over sodium sulphate. The crude 2-ethyl-2-methyl-indan, obtained as an oil after evaporating the solvent, is purified by chromatography on aluminium oxide/petroleum ether.

Aufarbeitung

  1. temperatureat reflux
  2. stirringThe reaction mixture is subsequently stirred
  3. temperatureat reflux for 28 hours
  4. temperaturecooled
  5. filtrationfiltered
  6. washthe residue is washed with water/petroleum ether
  7. extractionThe filtrate is extracted with petroleum ether
  8. extractionthe petroleum ether extract
  9. washis washed with water
  10. dry with materialdried over sodium sulphate

Quellen und Nachweise

ORD-Eintrag
ord-28adf486cf104b4d8d97dd240ed54f30
Quelldatensatz
uspto-grants-1979_08
Patentnummer
US04166131

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