Water → HCID 178511480, Verbindung

HRID 26158

Reaktionsgleichung

Reaktionsgleichung von HRID 26158
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][C:12]#[N:13])(=O)=[O:9])=[CH:4][CH:3]=1.[ClH:14].[NH2:15][OH:16].[OH2:17].C([O-])([O-])=O.[Na+].[Na+]>C(O)C>[Cl:14][C:2]1[CH:3]=[CH:4][C:5]([S:8]([CH2:11][C:12](=[NH:13])[NH:15][OH:16])(=[O:9])=[O:17])=[CH:6][CH:7]=1

Komponenten

6

Edukt 4

HCID 962Water2×HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 7358292-(4-Chlorobenzenesulfonyl)acetonitrile

Produkt 1

HCID 178511480HCID 178511480, VerbindungAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

50 g. (0.23 mole) of 4-chlorophenylsulfonylacetonitrile were dissolved in 1.5 liters of ethanol and 16 g. (0.23 mole) of hydroxylamine HCl in 150 ml. of water was added to this solution, followed by the addition of 14.4 g. (0.12 mole) of Na2CO3 in 150 ml. of water. This reaction mixture was stirred at room temperature overnight. 58 g. crude product were filtered off; this was recrystallized from about 2.5 liters of ethanol to give 40 g. of the product (70% yield).

Aufarbeitung

  1. additionfollowed by the addition of 14.4 g
  2. filtrationcrude product were filtered off
  3. customthis was recrystallized from about 2.5 liters of ethanol
  4. customto give 40 g

Quellen und Nachweise

ORD-Eintrag
ord-cfb04106ce044c1b82b83425a88a2633
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04148801

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