Br[CH2:2][C:3]([C:5](=[O:11])[C:6]([O:8][CH2:9][CH3:10])=[O:7])=O.[NH2:12][C:13]([NH2:15])=[S:14].C>O.C(O)C>[NH2:15][C:13]1[S:14][CH:2]=[C:3]([C:5](=[O:11])[C:6]([O:8][CH2:9][CH3:10])=[O:7])[N:12]=1195 g of ethyl bromoacetylglyoxylate are added dropwise to a solution of 66 g of thiourea in 450 ml of water and 450 ml of ethanol at 5° and after the addition has ended, the mixture is stirred at room temperature for 30 minutes and at 50° for 30 minutes and, after adding active charcoal, the resulting reaction mixture is then filtered. The filtrate is brought to pH 7 by adding sodium bicarbonate solution, whereupon ethyl 2-amino-thiazol-4-ylglyoxylate crystallizes out in crystals of melting point 147°.
Wird geladen…
